Cross-reactivity of fosphenytoin in four phenytoin immunoassays.
نویسندگان
چکیده
In: Brenner BM, ed. Brenner & Rector’s The kidney, 5th ed. Philadelphia: WB Saunders, 1996:1893–935. 3. Smith LH. The medical aspects of urolithiasis: an overview. J Urol 1989;141:707–10. 4. Mandel NS, Mandel GS. Urinary tract stone disease in the United States veteran population. II. Geographical analysis of variations in composition. J Urol 1989;142:1516–21. 5. Coe FL, Parks JH. New insights into the pathophysiology and treatment of nephrolithiasis: new research venues. J Bone Miner Res 1997; 12:522–33. 6. Ruml LA, Pearle MS, Pak CYC. Medical therapy. Calcium oxalate urolithiasis. Urol Clin North Am 1997;24:117–33. 7. Low RK, Stoller ML. Uric acid-related nephrolithiasis. Urol Clin North Am 1997;24:135–48.
منابع مشابه
Cross-reactivity of fosphenytoin in two human plasma phenytoin immunoassays.
The cross-reactivity of fosphenytoin, a phosphate ester prodrug of phenytoin, was investigated in the Abbott phenytoin TDx/TDxFLx fluorescence polarization immunoassay (TDx) and the Behring Diagnostics phenytoin Emit 2000 enzyme-multiplied immunoassay (Emit). The first part of our study investigating cross-reactivity utilized in vitro correlation of the two immunoassays with a validated and spe...
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Prodrugs are analogs of active drugs that have been developed to improve the bioavailability and/or tolerability of the latter. Fosphenytoin (1 ) and mycophenolate mofetil (MMF) (2 ) are two examples of prodrugs where monitoring of the active drug, the anticonvulsant phenytoin and the immunosuppressant mycophenolic acid (MPA), respectively, is used to guide therapy. The successful application o...
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BACKGROUND This investigation was undertaken to identify the structure of a novel immunoreactive metabolite derived from fosphenytoin that has been hypothesized previously as present in sera from renally impaired patients receiving this prodrug. METHODS The metabolite was isolated from uremic sera using solid-phase extraction and HPLC. Structural analysis was performed using HPLC-tandem mass ...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 44 3 شماره
صفحات -
تاریخ انتشار 1998